Brain cancer module: QLQ-BN Scope. The brain cancer module is meant for use among brain cancer patients varying in disease stage and treatment. The EORTC QLQ-BN20 questionnaire for assessing the health-related quality of life (HRQoL) in brain cancer patients: A phase IV validation. To be used in conjunction with the EORTC QLQ-C30 for measuring the health- related quality of life in patients with brain cancer.

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JewittWarren P. Thresholds of 1 SEM have also been suggested [ 11 ].

Prognostic implications of residual disease tumor-infiltrating lymphocytes and residual cancer burden in triple negative breast cancer patients after neo-adjuvant chemotherapy. Anchor-based methods link HRQoL measures to external criteria, either to a known indicator that has clinical relevance [e. How to cite this article: The development qlq-bbn20 psychometric validation of a brain cancer quality-of-life questionnaire for use in combination with general cancer-specific questionnaires.

J Can Res Ther ;2: Quality of life of lung cancer patients: Only two scales were suitable for anchoring with the MMSE: For illustration, the first difference in Qlq-bn200 mean change of adjacent categories is obtained as 4.

Analysis pertaining to physical and role functioning scales was restricted to Trial 1, which used version 3, the current version [ 19 ]. Table 5 presents distribution-based MCID estimates for comparison with anchor-based estimates in Tables 3 and 4.

Attention deficit hyperactivity disorder Primary malignant neoplasm of brain Bipolar Eodtc pediatric intracranial germ cell brain tumor. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License.

EORTC Quality of Life Questionnaire – Brain Cancer Module (EORTC QLQ-BN20)

Meaningful change in cancer-specific quality of life scores: Table 1 summarizes selected baseline demographic and clinical characteristics in the combined sample of all the patients from the two trials. The estimates could also be used as guidance for classification of patients by changes in HRQoL and symptoms over time. These 2 questionnaires were then compared with the original EORTC questionnaire and the second intermediate questionnaire was formed.


For each analysis, patients with data on an anchor and HRQoL scores qlq-gn20 2 or more time points were included. Separate analyses were eortcc for these two anchors. Interpretation of changes in health-related quality of life: For comparison purposes, four distribution-based approaches were applied: Thus, every study contributing to this question is important.

PF and RF are based on trial 1 only. Further investigation, if possible with other anchors, is therefore recommended. However, the evidence is not clear that a point threshold is applicable to each of the 15 QLQ-C30 scales qlq-b20 15 ].

EORTC QLQ-BN20 – EORTC Quality of Life Questionnaire – Brain Cancer Module

The Mini-Mental State Examination in general medical practice: Content validation of the FACT-Br with patients and health care professionals to eorrc quality of life in patients with brain metastases.

We acknowledge as a limitation that the observed correlations between the anchors and HRQoL scores were not strong.

Trial 1 reported by Stupp eprtc al. Prospective assessment of quality of life in adult patients with primary brain tumors in routine neurooncology practice. Translation and pilot validation of Hindi translation of assessing quality of life in patients with primary brain tumours using EORTC brain module BN In light of this, we restricted analysis of physical and role functioning domains only to the most recent version of the questionnaire; the one that uses the 4-point scale.

For interpretation, it could be recommended to augment the anchor-based MCID estimates with results from one of the distribution-based approaches by considering only those anchor-based MCID estimates at least equal to 0. This article has been cited by 1 Prospective assessment of quality of life in adult patients with primary brain tumors in routine neurooncology practice Budrukkar, A. Descriptive statistics summarizing the distributions of HRQoL scores at baseline are given in Table 2.


The increasingly frequent use of patient-reported health-related quality of life HRQoL as an outcome in cancer clinical trials over the years implies a greater need for meaningful interpretations of aggregated HRQoL scores.

Giant-cell arteritis without cranial manifestations presenting as fever of unknown origin: Anchor-based methods have been used previously to aid the interpretation of QLQ-C30 scores [ 1214 ]. More on this topic Health-related quality of life and sequelae in patients treated with brachytherapy and external beam irradiation for localized prostate cancer. Prosthetics and Orthotics International. Determining the minimal clinically important difference MCID [ 1 ] for HRQoL scores from cancer clinical trials is useful to clinicians, patients, and researchers as a benchmark for assessing the effectiveness of a health care intervention and for determining the sample size in a clinical trial.

Close mobile search navigation Article navigation. CoateChristine MasseyNatalie C. This article has been cited by. Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: Changes in MMSE of 4 or more points have been considered in the literature as clinically significant [ 2223 ].

Some authors suggest that 0. This provides further evidence that the 0.